Centre back Ramos having hurt his troublesome shoulder while scoring in Real Madrid's 3-2 defeat at Sevilla, and fullback Juanfran having sustained a thigh strain, both of them have withdrawn from the squad for this month's friendlies against England and Belgium.
Manchester City coach Manuel Pellegrini played down the significance of his tactical switch after a stoppage-time goal gave his team a win over Sevilla.
Manchester Police arrested 5 people, three of them Polish football fans, when a brawl broke out before the Man City v Sevilla game in the Champions League.