Centre back Ramos having hurt his troublesome shoulder while scoring in Real Madrid's 3-2 defeat at Sevilla, and fullback Juanfran having sustained a thigh strain, both of them have withdrawn from the squad for this month's friendlies against England and Belgium.
With coach Rafa Benitez under-fire for Real Madrid's perceived lack of attacking threat, the Spaniard needs Cristiano Ronaldo to return to his very best at Sevilla on Sunday.
Real Madrid came out on top against PSG as 1-0 winners in the Champions League group stage match. Here are the five major talking points from the match.