Valencia have some significant injury absentees but coach Nuno believes they still have enough quality to beat UCL Group H leaders Zenit St Petersburg.
Lionel Messi is set for his first start for nearly 2 months when Barcelona set their sights on Champions League qualification when Roma visit the Nou Camp.
John Terry believes Chelsea's fortunes could be changing as the struggling English champions travel to Israel with the prospect of securing qualification.
With coach Rafa Benitez under-fire for Real Madrid's perceived lack of attacking threat, the Spaniard needs Cristiano Ronaldo to return to his very best at Sevilla on Sunday.